Electrophoretic Variants in Enzymes
نویسندگان
چکیده
منابع مشابه
Electrophoretic variants of phosphoglucomutase in Saccharomyces species.
Strains of Saccharomyces cerevisiae and species with which S. cerevisiae is interfertile display a characteristic pattern of electrophoretic variants of phosphoglucomutase (PGM) consisting of a major component and one or two minor components, all of which migrate toward the cathode. The patterns are consistent with an earlier finding that two unlinked genes, one of which has two known alleles, ...
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HE activity of xanthine dehydrogenase (XDH) in Drosophila melanogaster is affected by mutations at three loci: ma4 at locus 64ion the X chromosome, ry at locus 52 ion the third chromosome, and lxd at locus 33 ? on the third chromosome. See GLASSMAN (1965) for a discussion of these loci. The ma4 and the ry mutants are deficient in XDH while lzd flies have 20 to 25% of the XDH activity of wild ty...
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Using starch-gel electrophoresis and appropriate stain ing, four variants have been found in erythrocytes from.the house mouse, Mus muscuius. An allele, designated Es-3 , controlling the presence of a fast-migrating esterase (designated Es-3d) has been found at the Es-3 locus. Tests of substrate specificity, heat sensitivity, and of eserine sulphate and iodoacetamide sensitivity, showed Es-3d ...
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Demonstrating that naturally occurring enzyme polymorphisms significantly impact metabolic pathway flux is a fundamental step in examining the possible adaptive significance of such polymorphisms. In earlier studies of the glucose-6-phosphate dehydrogenase (GGPD) polymorphism in Drosophila melanogaster, we used two different methods, exploiting both genotype-dependent interactions with the 6Pgd...
متن کاملLeukocyte alkaline phosphatase: electrophoretic variants associated with chronic myelogenous leukemia.
Starch-gel electrophoresis of leukocyte alkaline phosphatases, rendered soluble by treating normal leukocytes with butanol, revealed three electrophoretic variants of the enzyme. The phosphatases in similarly prepared extracts of leukemia cells differed from the normal isozymes in electrophoretic. mobility. A single variant was detected in one case of untreated leukemia; a similar component and...
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ژورنال
عنوان ژورنال: Science
سال: 1966
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.152.3725.1107